The Role of Androgen Deprivation Therapy In CArdiovascular Disease – A Longitudinal Prostate Cancer Study (RADICAL PC1) & A RAndomizeD Intervention for CArdiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (RADICAL PC2)
RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate cancer. RADICAL PC2 is a randomized, controlled trial of a systematic approach to modifying cardiovascular and lifestyle risk factors in men with a new diagnosis of prostate cancer.
RADICAL PC1 is observational and RADICAL PC2 is a randomized-controlled trial.
The primary objective of RADICAL PC1 is to determine the prevalence of cardiovascular risk factors and disease, and the incidence of major adverse cardiovascular events in men with prostate cancer and in particular men treated with Androgen Deprivation Therapy.
The primary objective of RADICAL PC2 is to determine whether a systematic cardiovascular and lifestyle risk factor modification strategy reduces the risk of major adverse cardiovascular events in men with a new diagnosis of prostate cancer or who are commencing Androgen Deprivation Therapy for the first time.
Jehonathan Pinthus; Darryl Leong
Prostate Cancer Canada