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Research

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PURE

Official Title

Prospective Urban and Rural Epidemiological Study

Status

Ongoing

Overview

To examine the impact of urbanization on the development of primordial risk factors (for example: physical activity and nutrition changes), primary risk factors (for example: obesity, hypertension, dysglycemia and dyslipidemia, smoking), and CVD.

Study Design

Prospective Cohort

Primary Endpoint

Adjudicated locally within each country. Each country will follow a similar protocol decided by the adjudicating committee.

Number of Patients

225000

Number of Sites

23

Number of Countries

25

Study Period

2002–TBA

Principal Investigator

Salim Yusuf

Program Manager

Sumathy Rangarajan, Gayle Lewis

Research Coordinator

Pam Mackie, SiuLim Chin, Shameena Ramacham

Key Publications

  • PURE Concept Paper, Int J Epidemiol. 2009 Mar 4: Environmental and societal influences acting on cardiovascular risk factors and disease at a population level: a review. Chow CK, Lock K, Teo K, Subramanian S, McKee M, Yusuf S
  • PURE Design Paper, Am Heart J. 2009 Jul;158(1):1-7.e1: The Prospective Urban Rural Epidemiology (PURE) study: examining the impact of societal influences on chronic non-communicable diseases in low-, middle-, and high-income countries. Teo K, Chow CK, Vaz M, Rangarajan S, Yusuf S; PURE Investigators-Writing Group
  • EPOCH Pilot paper – PLoS One. 2010 Dec 10;5(12):e14294
  • EPOCH Pilot – Cigarette pack labelling in 12 countries at different levels of economic development: J Public Health Policy. 2011 May;32(2):146-64

For more information, please visit http://www.phri.ca/pure