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Research

Photo for POISE-3

POISE-3

Official Title

PeriOperative ISchemic Evaluation-3 Trial

Status

Ongoing

Overview

An international multi-centre randomized clinical trial to assess the impact of tranexamic acid (TXA) versus placebo, and to assess the impact of managing hypotension versus standard of care in patients undergoing non-cardiac surgery who are at risk of a perioperative cardiovascular event.

Study Design

Multi-centre, blinded, randomized controlled trial

Primary Endpoint

Primary objective is to determine the incidence of a composite of myocardial infarction, stroke and pulmonary embolism. Patients will be followed for 1 year.

Number of Patients

10000

Number of Sites

300

Number of Countries

25

Study Period

2017-2022

Principal Investigator

PJ Devereaux

Program Manager

Shirley Pettit

Research Coordinator

Rosemary Howe

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