Prevention of Infections in Cardiac Surgery (PICS) PREVENA Vanguard Study
A cluster-randomized factorial crossover trial, comparing antibiotic mono-prophylaxis with Cefazolin vs. dual-prophylaxis with Cefazolin plus Vancomycin and conventional wound dressing vs. PREVENA negative-pressure wound management
Randomized 2×2 factorial cluster crossover study
The primary outcome of the vanguard study is adherence to the wound management system (Prevena) as per protocol; adherence to the antibiotic regime as per protocol; and loss of followup.
The primary outcome of the eventual full trial is to determine the effects of dual antibiotic prophylaxis and of a negative-pressure wound management system (Prevena) on deep and/or organ-space sternal surgical site infections (s-SSI).
Dominik Mertz, PJ Devereaux, Stuart Connolly, Andre Lamy, Richard Whitlock, Michael McGillion