Prevention of Arrhythmia Device Infection Trial
To compare a conventional antibiotic therapy approach to an aggressive antibiotic therapy for the prevention of hospitalization for device infection in high-risk patients undergoing arrhythmia device procedures. Eligible and consenting patients will be randomized to conventional (pre-op antibiotics) or aggressive antibiotics (pre-op, intra-op and post-op) for the prevention of infection prior to the planned device procedure. Patients will have a follow up 12 months post-implant to determine if they met the primary outcome for hospitalization for device infection.
Randomized, Pilot Study.
Hospitalization attributed to device infection, device infection not requiring surgical intervention, treatment with antibiotics for suspected device infection, antibiotic related adverse events, prolongation of hospitalization due to proven or suspected adverse events from the antibiotic therapy, cost benefit analysis
Andrew Krahn (PI) and Stuart Connolly (Steering Committee Chair)