Prevention of Arrhythmia Device Infection Trial (PADIT) Cluster Crossover Study Pilot
To compare whether a centre-wide policy of incremental antibiotic therapy will reduce hospitalization for device infection compared to a policy of conventional antibiotic prophylaxis in high-risk patients undergoing arrhythmia device procedures. This pilot study will provide feasibility information for a larger cluster randomized crossover design.
Randomized, Cluster Crossover.
Hospitalization attributed to device infection, device infection not requiring surgical intervention, treatment with antibiotics for suspected device infection, antibiotic related adverse events, prolongation of hospitalization due to proven or suspected adverse events from the antibiotic therapy
Andrew Krahn (PI) and Stuart Connolly (Steering Committee Chair)