A Clinical Trial Evaluating the Effect of Glucose-Insulin-Potassium Infusion on Mortality in Patients With Acute ST-Segment Elevation Myocardial Infarction
To evaluate the effects of high-dose glucose, insulin, and potassium (GIK) on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation. GIK infusion in patients with STEMI had no significant impact on mortality and other major cardiac events.
Randomized, controlled trial with partial 2×2 factorial design.
The primary outcome measure was mortality from any cause at 30 days after randomization. Secondary outcome measures included the composite of death or nonfatal cardiac arrest, death or cardiogenic shock, death or reinfarction, and each of these individually.
Salim Yusuf, Shamir Mehta