A Randomized Trial of Influenza Vaccine to Prevent Adverse Vascular Events
To assess the feasibility of randomizing heart failure (HF) patients to either inactivated influenza vaccine or to placebo to assess whether influenza vaccine can reduce adverse vascular events in this population. Demonstration of influenza vaccine leading to a reduction in major adverse vascular events in HF patients would lead to a major change in how these patients are managed.
Randomized, multicenter, placebo controlled, pilot trial.
A composite of major adverse vascular events, including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and hospitalization for heart failure.
Mark Loeb, Hisham Dokainish