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Research

Photo for INTERSTROKE

INTERSTROKE

Official Title

INTERSTROKE is a Study of the Importance of Conventional and Emerging Risk Factors of Stroke in Different Regions and Ethnic Groups of the World

Status

Completed

Overview

Stroke is the most common cause of adult disability and the third leading cause of death worldwide, most of which occurs in low-income countries. An effective global strategy to reduce the risk of premature stroke mandates systematic evaluation of the contribution of important risk factors in various ethnic groups and geographical locations. The overwhelming success of INTERHEART has afforded enormous insights into our knowledge of risk factors for myocardial infarction [MI] in different regions of the world and among different ethnic groups. As a result, it has armed public health policy makers with critical information to develop population-based approaches to prevent MI. Similar data are needed to help in the prevention of stroke.

Study Design

Case-control

Primary Endpoint

Risk factors for stroke (Not adjudicated).

Number of Patients

27606

Number of Sites

177

Number of Countries

32

Study Period

2007–2014

Principal Investigator

Martin O’Donnell

Program Manager

Sumathy Rangarajan

Research Coordinator

Siu Lim Chin

Key Publications

O’Donnell MJ, Xavier D, Liu L et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet 2010;376(9735):112-123.

O’Donnell M, Yusuf S. Tackling the global burden of stroke: the need for large-scale international studies. Lancet Neurol 2009;8(4):306-307.

O’Donnell M, Xavier D, Diener C et al. Rationale and design of INTERSTROKE: a global case-control study of risk factors for stroke. Neuroepidemiology 2010;35(1):36-44.

O’Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, Rangarajan S, Islam S, Pais P, McQueen MJ, Mondo C, Damasceno A, Lopez-Jaramillo P, Hankey GJ, Dans AL, Yusoff K, Truelsen T, Diener HC, Sacco RL, Ryglewicz D, Czlonkowska A, Weimar C, Wang X, Yusuf S; INTERSTROKE investigators. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010; 376(9735):112-23.

O’Donnell MJ, Chin SL, Rangarajan S, Xavier D, Liu L, Zhang H, Rao-Melacini P, Zhang X, Pais P, Agapay S, Lopez-Jaramillo P, Damasceno A, Langhorne P, McQueen MJ, Rosengren A, Dehghan M, Hankey GJ, Dans AL, Elsayed A, Avezum A, Mondo C, Diener HC, Ryglewicz D, Czlonkowska A, Pogosova N, Weimar C, Iqbal R, Diaz R, Yusoff K, Yusufali A, Oguz A, Wang X, Penaherrera E, Lanas F, Ogah OS, Ogunniyi A, Iversen HK, Malaga G, Rumboldt Z, Oveisgharan S, Al Hussain F, Magazi D, Nilanont Y, Ferguson J, Pare G, Yusuf S; INTERSTROKE investigators. Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet. 2016; 388(10046):761-75.

Langhorne P, O’Donnell MJ, Chin SL, Zhang H, Xavier D, Avezum A, Mathur N, Turner M, MacLeod MJ, Lopez-Jaramillo P, Damasceno A, Hankey GJ, Dans AL, Elsayed A, Mondo C, Wasay M, Czlonkowska A, Weimar C, Yusufali AH, Hussain FA, Lisheng L, Diener HC, Ryglewicz D, Pogosova N, Iqbal R, Diaz R, Yusoff K, Oguz A, Wang X, Penaherrera E, Lanas F, Ogah OS, Ogunniyi A, Iversen HK, Malaga G, Rumboldt Z, Magazi D, Nilanont Y, Rosengren A, Oveisgharan S, Yusuf S; INTERSTROKE collaborators. Practice patterns and outcomes after stroke across countries at different economic levels (INTERSTROKE): an international observational study. Lancet. 2018; 391(10134):2019-2027.