Impact of short-course colchicine versus placebo after pulmonary vein isolation: a pilot study
Recurrence is a common problem after catheter ablation for atrial fibrillation (AF), affecting at least one out of three patients.
Inflammation due to the procedure may contribute to pulmonary vein reconnection and, thus, failure of catheter ablation.
This pilot study will assess whether a randomized, placebo-controlled trial investigating a 10-day treatment with colchicine, a potent anti-inflammatory drug, to improve patient relevant outcomes after catheter ablation for atrial fibrillation is feasible.
Alexander Benz, Stuart Connolly, Jeff Healey, Guy Amit