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Research

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DEPOSITION

Official Title

DEcreasing POStoperatIve Blood Loss by Topical vs. Intravenous Tranexamic Acid in OpeN Cardiac Surgery

Status

Ongoing

Overview

To determine in patients undergoing on-pump cardiac surgery, whether topical tranexamic acid (intra-pericardial/mediastinal delivery) compared to the usual intravenous TxA administration reduces the proportion of patients receiving inhospital red blood cell transfusion.

Study Design

Single-centre randomized controlled clinical trial

Primary Endpoint

The proportion of patients receiving in-hospital red blood cell transfusion

Number of Patients

500

Number of Sites

1

Number of Countries

1

Study Period

2019-2021

Principal Investigator

Andre Lamy, PJ Devereaux, Richard Whitlock, Yannick Lemanach, Emilie Belley-Cote, Julian Own, Jessica Spence, Michael McGillion, Tomas VanHelder, Alison Fox-Robichaud

Program Manager

Shirley Pettit

Research Coordinator

Ingrid Copland