The Direct Oral Anticoagulation versus Warfarin after Cardiac Surgery (DANCE) Pilot Trial
DANCE Pilot is looking at the feasiblity of conducting a large RCT comparing the safety of direct oral anticoagulants (DOAC) versus warfarin in the early period (30 days) after cardiac surgery in patients with an indication for oral anticoagulation.
Multi-centre, randomized controlled trial
Primary Feasibility Outcomes:
1. Ability to recruit an average of 5 patients per centre per month,
2. The ability to have < 5% of patients crossover OAC arms,
3. Complete 30-day follow-up in ≥ 95% of enrolled patients.
Most Important Secondary Outcome:
Major bleeding over follow-up as defined by the International Society of Thrombosis and Hemostasis.
Emilie Belley-Côté, Richard Whitlock