GLOBAL HEALTH | GLOBAL PARTNERSHIPS | GLOBAL IMPACT

Research

Photo for DANCE Pilot

DANCE Pilot

Official Title

The Direct Oral Anticoagulation versus Warfarin after Cardiac Surgery (DANCE) Pilot Trial

Status

Ongoing

Overview

DANCE Pilot is looking at the feasiblity of conducting a large RCT comparing the safety of direct oral anticoagulants (DOAC) versus warfarin in the early period (30 days) after cardiac surgery in patients with an indication for oral anticoagulation.

Study Design

Multi-centre, randomized controlled trial

Primary Endpoint

Primary Feasibility Outcomes:
1. Ability to recruit an average of 5 patients per centre per month,
2. The ability to have < 5% of patients crossover OAC arms,
3. Complete 30-day follow-up in ≥ 95% of enrolled patients.

Most Important Secondary Outcome:
Major bleeding over follow-up as defined by the International Society of Thrombosis and Hemostasis.

Number of Patients

200

Number of Sites

5

Number of Countries

1

Study Period

2019-2021

Principal Investigator

Emilie Belley-Côté, Richard Whitlock

Program Manager

Jessica Vincent

Research Coordinator

David Stillo