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Research

Photo for CORONARY

CORONARY

Official Title

CABG Off or On Pump Revascularization Study (CORONARY)

Status

Ongoing

Overview

To compare the risks & benefits of Off-pump Coronary artery bypass surgery (CABG) to On-pump CABG & to determine if one is better than the other. Also to see the rate of recruitment with expertise-based randomization across different hospital settings. The study will look at which of the two techniques reduce major risks associated with CABG.

Study Design

Randomized, treatment, open label, active control, parallel group design.

Primary Endpoint

The occurrence of the composite of total mortality, stroke, nonfatal MI, or new renal failure at 30 days post CABG surgery. The occurrence of the composite of total mortality, stroke, nonfatal MI, new renal failure, or repeat coronary revascularization (i.e. coronary artery bypass surgery or percutaneous coronary intervention) over 5 years after randomization. Secondary Endpoint: The assessment of total costs and resources consumption at 30 days after CABG surgery. The assessment of total costs and resources consumption at 5 years after CABG surgery. All endpoints are adjudicated.

Number of Patients

4700

Number of Sites

79

Number of Countries

19

Study Period

2011–2014

Principal Investigator

Andre Lamy

Program Manager

Susan Chrolavicius, Shirley Pettit

Research Coordinator

Yongning Ou

Key Publications

  • Effects of off-pump and on-pump coronary-artery bypass grafting at 1 year.
  • Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Paolasso E, Straka Z, Piegas LS, Akar AR, Jain AR, Noiseux N, Padmanabhan C, Bahamondes JC, Novick RJ, Vaijyanath P, Reddy SK, Tao L, Olavegogeascoechea PA, Airan B, Sulling TA, Whitlock RP, Ou Y, Pogue J, Chrolavicius S, Yusuf S; CORONARY Investigators.
  • N Engl J Med. 2013 Mar 28;368(13):1179-88. doi: 10.1056/NEJMoa1301228. Epub 2013 Mar 11.
  • Coronary Artery Bypass Grafting Surgery Off- or On-pump Revascularisation Study (CORONARY): kidney substudy analytic protocol of an international randomised controlled trial.
  • Garg AX, Devereaux PJ, Yusuf S, Cuerden MS, Parikh CR, Coca SG, Walsh M, Cook RJ, Whitlock RP, Noiseux N, Novick RJ, Ou Y, Lamy A; CORONARY Investigators.
  • BMJ Open. 2012 Apr 18;2(2):e001080. doi: 10.1136/bmjopen-2012-001080. Print 2012.
  • Off-pump or on-pump coronary-artery bypass grafting at 30 days.
  • Lamy A, Devereaux PJ, Prabhakaran D, Taggart DP, Hu S, Paolasso E, Straka Z, Piegas LS, Akar AR, Jain AR, Noiseux N, Padmanabhan C, Bahamondes JC, Novick RJ, Vaijyanath P, Reddy S, Tao L, Olavegogeascoechea PA, Airan B, Sulling TA, Whitlock RP, Ou Y, Ng J, Chrolavicius S, Yusuf S; CORONARY Investigators.
  • N Engl J Med. 2012 Apr 19;366(16):1489-97. doi: 10.1056/NEJMoa1200388. Epub 2012 Mar 26.
  • Rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery.
  • Lamy A, Devereaux PJ, Prabhakaran D, Hu S, Piegas LS, Straka Z, Paolasso E, Taggart D, Lanas F, Akar AR, Jain A, Noiseux N, Ou Y, Chrolavicius S, Ng J, Yusuf S.
  • Am Heart J. 2012 Jan;163(1):1-6. doi: 10.1016/j.ahj.2011.10.007.