completed

The objective of the EpiDREAM study was to determine if 16 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes (T2DM) in Europeans are also associated with T2DM in South Asians and Latinos and if they can add to the prediction of incident T2DM in a high-risk population.

Physical measures, questionnaires, and blood samples were collected from 25,063 individuals at risk for dysglycemia.

Sixteen SNPs that have been robustly associated with T2DM in Europeans were genotyped.

Among 15,466 European, South Asian, and Latino subjects, we examined the association of these 16 SNPs alone and combined in a gene score with incident cases of T2DM (n = 1,016) that developed during 3.3 years of follow-up.

Study Type

Observational

Study Design

Prospective cohort

NO. of Countries

21

NO. of Sites

191

NO. of Participants

15466

Study Period

2008-2010

Sponsor

PHRI

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