Tetralogy of Fallot for Life
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart defect with a global incidence rate 38,000 patients annually. TOF is a life-long condition and requires long-term follow-up and often multiple cardiac re-interventions. Despite the improved early survival with surgical repair, evidence suggest that certain repair techniques are associated with long-term complications of right heart failure and sudden cardiac death. The TOF LIFE study will increase the understanding of current TOF surgical practices globally, the impact of repair technique on right heart function, and the resultant life-long morbidity and mortality. TOF LIFE is a prospective, international, observational inception cohort study that will be recruiting participants from large pediatric cardiac centers globally.
International multi-centre inception cohort study
Primary outcome is right ventricular morphology and physiology at 2 years post-repair as measured by echocardiography.
Richard Whitlock, Glen Van Arsdell
Sara Hussain (Research Fellow), Ingrid Copland
International Congenital Cardiac Study Group