Perioperative Ischemic Evaluation Study (POISE) Trial
To evaluate the effects of metoprolol (a beta-blocker drug) on the prevention heart attacks and deaths around the time of noncardiac surgery. POISE is one of the largest trials in perioperative medicine and has had a significant impact on guidelines and patterns of practice.
Randomized, double-blind (subject, caregiver, investigator, outcomes assessor), placebo control, parallel group design, efficacy study.
Major cardiovascular events (defined as cardiovascular death, nonfatal myocardial infarction, or nonfatal cardiac arrest); Secondary endpoints: Clinically significant atrial fibrillation re-hospitalization for cardiac reasons. Nonfatal myocardial infarction. Nonfatal cardiac arrest. Cardiovascular death. Total mortality. Revascularization procedures (i.e. coronary artery bypass surgery and percutaneous transluminal coronary angioplasty). Congestive heart failure. Clinically significant bradycardia. Clinically significant hypotension. Nonfatal stroke. All primary and secondary events were adjudicated.