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SECURE

Official Title

The Study to Evaluate Carotid Ultrasound Changes in Patients Treated With Ramipril and Vitamin E (SECURE)

Status

Completed

Overview

To evaluate the effects of long-term treatment with the angiotensin-converting enzyme inhibitor ramipril and vitamin E on atherosclerosis progression in high-risk patients.

Study Design

Randomized, double-blind with parallel group designs and a 3X2 factorial design

Primary Endpoint

Atherosclerosis progression

Number of Patients

732

Number of Sites

6

Number of Countries

1

Study Period

1993–1995

Principal Investigator

Eva Lonn, Salim Yusuf

Program Manager

Not Applicable

Research Coordinator

Jackie Bosch

Key Publications

Lonn E, Yusuf S, Dzavik V, Doris I, Yi Q, Smith S, Moore-Cox A, Bosch J, Riley WA, Teo KK, for the SECURE Investigators. Effects of ramipril and of vitamin E on atherosclerosis: results of the prospective randomized Study to Evaluate Carotid Ultrasound changes in patients treated with Ramipril and vitamin E (SECURE). Circulation 2001;103:919-925.