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NIATH

Official Title

A preliminary study of Non-Invasive measures of ATHerosclerosis in children at high risk of developing atherosclerosis

Status

Completed

Overview

To determine if non-invasive measures of atherosclerosis will be abnormal in children with increased risk for developing coronary artery disease, including children with hyperlipidemia, with diabetes (Type 1 or 2) and who are obese.

Study Design

Cross-sectional study comparing cardiovascular risk factors and non-invasive measures of atherosclerosis in children with conditions that are associated with increased cardiovascular risk (hyperlipidemia, obesity and diabetes (Types 1 & 2)).

Primary Endpoint

Primary: IMT & BAR measures in children age 5 – 18 years and measures of cardiovascular risk, obesity and diabetes. Secondary: Measures of environmental factors and Family History

Number of Patients

200

Number of Sites

1

Number of Countries

1

Study Period

2003–2013

Principal Investigator

Eva Lonn, Katherine Morrison

Program Manager

Sumathy Rangarajan

Research Coordinator

Not Applicable

Collaborators

CIHR

Key Publications

Morrison KM, Dyal L, Conner W, Helden E, Newkirk L, Yusuf S, Lonn E. Cardiovascular risk factors and non-invasive assessment of subclinical atherosclerosis in youth. Atherosclerosis, 208(2):501-05, 2010. doi: 10.1016/j.atherosclerosis.2009.07.034