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IMPROVE-PVI Pilot

Official Title

Impact of short-course colchicine versus placebo after pulmonary vein isolation: a pilot study

Status

Ongoing

Overview

Recurrence is a common problem after catheter ablation for atrial fibrillation (AF), affecting at least one out of three patients.

Inflammation due to the procedure may contribute to pulmonary vein reconnection and, thus, failure of catheter ablation.

This pilot study will assess whether a randomized, placebo-controlled trial investigating a 10-day treatment with colchicine, a potent anti-inflammatory drug, to improve patient relevant outcomes after catheter ablation for atrial fibrillation is feasible.

Number of Patients

200

Number of Sites

1

Number of Countries

1

Study Period

2019-2021

Principal Investigator

Alexander Benz, Stuart Connolly, Jeff Healey, Guy Amit

Program Manager

Heather Beresh

Research Coordinator

Toni Newman