Thiazolidinedione Intervention with vitamin D Evaluation (TIDE)
To evaluate the effect of treatment with thiazolidineiones (TZD) on cardiovascular morbidity and mortality and is expected to be the definitive trial regarding the role of TZDs in the prevention of cardiovascular events in people with type 2 diabetes mellitus
Randomized, treatment, open label, parallel group design.
the composite of CV death, non-fatal MI, non-fatal stroke, and significant heart failure; Secondary endpoints: he composite of CV death, nonfatal myocardial infarction, or nonfatal stroke, revascularization, hospitalization for congestive heart failure; total mortality; cardiovascular mortality; major coronary heart disease events, total strokes, microvascular complications of diabetes. All endpoints are adjudicated