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Research

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TCOM

Official Title

Transcutaneous oximetry, transcutaneous carbon dioxide and supplemental oxygen therapy in lower limb amputations – An observational study

Status

Ongoing

Overview

To determine the ability of transcutaneous oximetry and transcutaneous carbon dioxide measurements in the legs of patients undergoing below-knee amputation to predict amputation wound healing failure and revision.

Study Design

Observational study

Primary Endpoint

1) To determine the ability of transcutaneous oximetry and transcutaneous CO2 measurements in the legs of patients undergoing below-knee amputation to predict amputation wound healing failure (defined as the need for amputation revision) and all-cause mortality at 30-days post-amputation.
2) To determine an optimum cut-off value for both transcutaneous oximetry and transcutaneous CO2 levels for predicting the occurrence of the first co-primary outcome (revision amputation to higher level or mortality).

Number of Patients

41

Number of Sites

3

Number of Countries

1

Study Period

2012–2014

Principal Investigator

Richard Whitlock

Program Manager

Susan Chrolavicius, Shirley Pettit

Research Coordinator

Jessica Vincent

Collaborators

CIHR