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Research

Photo for ORIGINALE

ORIGINALE

Official Title

ORIGIN And Legacy Effects

Status

Completed

Overview

To continue to follow patients in an observational study to the ORIGIN Trial.

Study Design

Observational Extension study

Primary Endpoint

The composite of CV death, non-fatal MI, non-fatal stroke, and significant heart failure. Secondary endpoints: Decline in the ability to perform everyday activities (key secondary outcome), Renal dysfunction (Primary outcome: end stage renal disease [ESRD] requiring dialysis or transplantation or doubling of serum creatinine), Total mortality. All primary and secondary endpoints are adjudicated.

Number of Patients

8000

Study Period

2010–2013

Principal Investigator

Hertzel Gerstein, Zubin Punthakee

Program Manager

Jackie Bosch

Research Coordinator

Jessica Tyrwhitt