ORIGIN And Legacy Effects
To continue to follow patients in an observational study to the ORIGIN Trial.
Observational Extension study
The composite of CV death, non-fatal MI, non-fatal stroke, and significant heart failure. Secondary endpoints: Decline in the ability to perform everyday activities (key secondary outcome), Renal dysfunction (Primary outcome: end stage renal disease [ESRD] requiring dialysis or transplantation or doubling of serum creatinine), Total mortality. All primary and secondary endpoints are adjudicated.
Hertzel Gerstein, Zubin Punthakee