A Randomized Trial of Influenza Vaccine to Prevent Adverse Vascular Events
Evidence exists that influenza increases adverse vascular events. However whether influenza vaccination can reduce adverse vascular events remains controversial. The goal of this study is to randomize patients with heart failure to either inactivated influenza vaccine or to placebo to assess whether influenza vaccine can reduce adverse vascular events.
The IVVE study is a multi-centre, randomized, placebo controlled trial.
The primary endpoint is a composite of cardiovascular death, non-fatal myocardial infarction, non-fata stroke and hospitalizations for heart failure.
Mark Loeb, Hisham Dokainish