The Homocysteine and Atherosclerosis Reduction Trial (HART)
To evaluate the effects of homocysteine-lowering vitamin therapy on the progression of carotid atherosclerosis, as evaluated by serial B-mode quantitative ultrasound (US) examinations. A substudy of the HOPE-2 trial.
Randomized, double-blind, multicenter, international, placebo-controlled trial
The primary study outcome was the composite of CV death, myocardial infarction and stroke.
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- Held C, Sumner G, Sheridan P, McQueen M, Smith S, Dagenais G, Yusuf S, Lonn E. Correlations between plasma homocysteine and folate concentrations and carotid atherosclerosis in high-risk individuals: baseline data from the Homocysteine and Atherosclerosis Reduction Trial (HART). Vasc Med. 2008 Nov;13(4):245-53. doi: 10.1177/1358863X08092102.