Beta Blockers and Angiotensin Receptor Blockers in Bicuspid Aortic Valve Disease Aortopathy (BAV Study)
To evaluate the efficacy of beta blockers and angiotensin receptor blockers in the prevention of aortic dilatation and associated complications in adults with bicuspid aortic valve (BAV) disease.
Randomized, double-blind, prospective, multicentre, placebo-controlled, two-arm trial of adult patients with bicuspid aortic valve aortopathy.
The primary outcome is the change from baseline in the ascending aorta size, which will be evaluated by MRI scanning. Secondary outcome is rate of change in ascending aorta size using transthoracic echocardiography.
Investigators on behalf of the Canadian Adult Congenital Heart (CACH) Disease Network