Dr. PJ Devereaux MD, PhD, FRCP(C), McMaster University

Publications are listed in chronological order by descending date. Link takes user to pubMed for publication details.

• Immune biomarkers predictive of respiratory viral infection in elderly nursing home residents.

  Source: PLoS One

• The Cost Implications of Off-Pump Versus On-Pump Coronary Artery Bypass Graft Surgery at One Year.

  Source: Ann Thorac Surg

• The safety of addition of nitrous oxide to general anaesthesia in at-risk patients having major non-cardiac surgery (ENIGMA-II): a randomised, single-blind trial.

  Source: Lancet

• Kidney Function and Population-Based Outcomes of Initiating Oral Atenolol Versus Metoprolol Tartrate in Older Adults.

  Source: Am J Kidney Dis

• Myocardial injury after noncardiac surgery.

  Source: Curr Opin Cardiol

• How to read a systematic review and meta-analysis and apply the results to patient care: users’ guides to the medical literature.

  Source: JAMA

• Perceptions of authors’ contributions are influenced by both byline order and designation of corresponding author.

  Source: J Clin Epidemiol

• Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of f

  Source: BMC Musculoskelet Disord

• Clinical Outcomes with ?-blockers for Myocardial Infarction A Meta-Analysis of Randomized Trials.

  Source: Am J Med

• Rationale and design of the PeriOperative ISchemic Evaluation-2 (POISE-2) trial: an international 2 × 2 factorial randomized controlled trial of acetyl-salicylic acid vs. placebo and clonidine vs. placebo in patients undergoing noncardiac surgery.

  Source: Am Heart J

• Kidney function after off-pump or on-pump coronary artery bypass graft surgery: a randomized clinical trial.

  Source: JAMA

• Values and preferences for oral antithrombotic therapy in patients with atrial fibrillation: physician and patient perspectives.

  Source: Health Expect

• Rationale and design of the steroids in cardiac surgery trial.

  Source: Am Heart J

• In reply.

  Source: Anesthesiology

• Immunosenescence in the nursing home elderly.

  Source: BMC Geriatr

• Cardiac biomarkers in the prediction of risk in the non-cardiac surgery setting.

  Source: Anaesthesia

• Association between angiotensin converting enzyme inhibitor or angiotensin receptor blocker use prior to major elective surgery and the risk of acute dialysis.

  Source: BMC Nephrol

• Aspirin in patients undergoing noncardiac surgery.

  Source: N Engl J Med

• Clonidine in patients undergoing noncardiac surgery.

  Source: N Engl J Med

• Accelerated versus standard care in hip fracture patients: does speed save lives?

  Source: J Comp Eff Res

• Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial.

  Source: BMJ Open

• Aspirin and clonidine in non-cardiac surgery: acute kidney injury substudy protocol of the Perioperative Ischaemic Evaluation (POISE) 2 randomised controlled trial.

  Source: BMJ Open

• Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes.

  Source: Anesthesiology

• The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility Index.

  Source: J Clin Epidemiol

• Radiographic prevalence of CAM-type femoroacetabular impingement after open reduction and internal fixation of femoral neck fractures.

  Source: Knee Surg Sports Traumatol Arthrosc

• Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol.

  Source: Trials

• Accelerated care versus standard care among patients with hip fracture: the HIP ATTACK pilot trial.

  Source: CMAJ

• When it comes to trials, do we get what we pay for?

  Source: N Engl J Med

• The risk of perioperative bleeding in patients with chronic kidney disease: a systematic review and meta-analysis.

  Source: Ann Surg

• The prognostic value of pre-operative and post-operative B-type natriuretic peptides in patients undergoing noncardiac surgery: B-type natriuretic peptide and N-terminal fragment of pro-B-type natriuretic peptide: a systematic review and individual patien

  Source: J Am Coll Cardiol

• Left Atrial Appendage Occlusion Study II (LAAOS II).

  Source: Can J Cardiol

• Randomized clinical trials–removing unnecessary obstacles.

  Source: N Engl J Med

• The association between perioperative hemoglobin and acute kidney injury in patients having noncardiac surgery.

  Source: Anesth Analg

• Impact of tuberculosis on mortality among HIV-infected patients receiving antiretroviral therapy in Uganda: a prospective cohort analysis.

  Source: AIDS Res Ther

• Ninety-minute vs 3-h performance of high-sensitivity cardiac troponin assays for predicting hospitalization for acute coronary syndrome.

  Source: Clin Chem

• Off-pump or on-pump coronary-artery bypass grafting.

  Source: N Engl J Med

• Relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery: toward an empirical definition of hypotension.

  Source: Anesthesiology

• Femoral neck shortening after internal fixation of a femoral neck fracture.

  Source: Orthopedics

• Rationale and design of the Primary pREvention strategies at the community level to Promote Adherence of treatments to pREvent cardiovascular diseases trial number (CTRI/2012/09/002981).

  Source: Am Heart J

• Protocol understanding and anxiety in perioperative clinical trial patients approached for consent on the day of surgery.

  Source: Mayo Clin Proc

• Cognitive dysfunction in hip fracture patients.

  Source: Orthop Clin North Am

• Postoperative B-type natriuretic peptide for prediction of major cardiac events in patients undergoing noncardiac surgery: systematic review and individual patient meta-analysis.

  Source: Anesthesiology

• Effects of off-pump and on-pump coronary-artery bypass grafting at 1 year.

  Source: N Engl J Med

• Implications of adjustment of high-sensitivity cardiac troponin T assay.

  Source: Clin Chem

• Nitrous oxide and serious morbidity and mortality in the POISE trial.

  Source: Anesth Analg

• Central statistical monitoring: detecting fraud in clinical trials.

  Source: Clin Trials

• Emerging trends in clinical trial design.

  Source: Anesth Analg

• Troponin T level and mortality risk after noncardiac surgery: practical implications of the VISION study.

  Source: Pol Arch Med Wewn

• Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia.

  Source: Diabet Med

• A meta-analysis of randomized controlled trials comparing percutaneous coronary intervention with medical therapy in stable angina pectoris.

  Source: Can J Cardiol

• Bias towards dementia: are hip fracture trials excluding too many patients? A systematic review.

  Source: Injury

• The coronary CT angiography vision protocol: a prospective observational imaging cohort study in patients undergoing non-cardiac surgery.

  Source: BMJ Open

• Revisiting sample size: are big trials the answer?

  Source: J Bone Joint Surg Am

• Emerging designs in orthopaedics: expertise-based randomized controlled trials.

  Source: J Bone Joint Surg Am

• Evolution of heterogeneity (I2) estimates and their 95% confidence intervals in large meta-analyses.

  Source: PLoS One

• Secular trends in acute dialysis after elective major surgery–1995 to 2009.

  Source: CMAJ

• ACP Journal Club. Review: Perioperative statins reduce perioperative MI and AF in statin-naïve patients.

  Source: Ann Intern Med

• Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery.

  Source: JAMA

• Assessment and implication of prognostic imbalance in randomized controlled trials with a binary outcome–a simulation study.

  Source: PLoS One

• Designing and analyzing clinical trials with composite outcomes: consideration of possible treatment differences between the individual outcomes.

  Source: PLoS One

• Coronary Artery Bypass Grafting Surgery Off- or On-pump Revascularisation Study (CORONARY): kidney substudy analytic protocol of an international randomised controlled trial.

  Source: BMJ Open

• The potential role of ?(2) agonists for noncardiac surgery.

  Source: Anesthesiology

• Off-pump or on-pump coronary-artery bypass grafting at 30 days.

  Source: N Engl J Med

• The need for large clinical studies in perioperative medicine.

  Source: Anesthesiology

• The use of transcutaneous oximetry to predict healing complications of lower limb amputations: a systematic review and meta-analysis.

  Source: Eur J Vasc Endovasc Surg

• Central coordination as an alternative for local coordination in a multicenter randomized controlled trial: the FAITH trial experience.

  Source: Trials

• Rationale and design of the coronary artery bypass grafting surgery off or on pump revascularization study: a large international randomized trial in cardiac surgery.

  Source: Am Heart J

• The use of transcutaneous oximetry to predict complications of chronic wound healing: a systematic review and meta-analysis.

  Source: Wound Repair Regen

• CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials.

  Source: Int J Surg

• The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis–a simulation study.

  Source: PLoS One

• CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials.

  Source: Int J Surg

• Biomarkers for predicting serious cardiac outcomes at 72 hours in patients presenting early after chest pain onset with symptoms of acute coronary syndromes.

  Source: Clin Chem

• Authors’ reply.

  Source: Indian J Orthop

• Multiplex protein assay performance/evaluation and the requirement for precision and correlation to clinical assays.

  Source: Clin Chem Lab Med

• Impact of preoperative maintenance or interruption of aspirin on thrombotic and bleeding events after elective non-cardiac surgery: the multicentre, randomized, blinded, placebo-controlled, STRATAGEM trial.

  Source: Br J Anaesth

• Cardiac troponin testing in the acute care setting: ordering, reporting, and high sensitivity assays–an update from the Canadian society of clinical chemists (CSCC).

  Source: Clin Biochem

• GRADE guidelines 6. Rating the quality of evidence–imprecision.

  Source: J Clin Epidemiol

• High sensitivity troponin T concentrations in patients undergoing noncardiac surgery: a prospective cohort study.

  Source: Clin Biochem

• Characteristics and short-term prognosis of perioperative myocardial infarction in patients undergoing noncardiac surgery: a cohort study.

  Source: Ann Intern Med

• Statin use associates with a lower incidence of acute kidney injury after major elective surgery.

  Source: J Am Soc Nephrol

• Outcomes assessment in the SPRINT multicenter tibial fracture trial: Adjudication committee size has trivial effect on trial results.

  Source: J Clin Epidemiol

• Essay for the CIHR/CMAJ award: impact of the Perioperative Ischemic Evaluation (POISE) trial.

  Source: CMAJ

• Prevention of peptic ulcers with esomeprazole in patients at risk of ulcer development treated with low-dose acetylsalicylic acid: a randomised, controlled trial (OBERON).

  Source: Heart

• The optimal timing of smoking cessation before surgery: Comment on “Smoking cessation shortly before surgery and postoperative complications”.

  Source: Arch Intern Med

• Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: a simulation study.

  Source: BMC Med Res Methodol

• Prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurement after noncardiac surgery: a systematic review and meta-analysis.

  Source: Anesthesiology

• Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group.

  Source: Trials

• Surgery for hip fractures: Does surgical delay affect outcomes?

  Source: Indian J Orthop

• An international prospective cohort study evaluating major vascular complications among patients undergoing noncardiac surgery: the VISION Pilot Study.

  Source: Open Med

• Beta 2 antagonism in acute respiratory failure.

  Source: Crit Care

• A survey evaluating surgeons’ peri-operative usage of acetyl-salicylic acid (ASA) and their willingness to enroll their patients in a perioperative ASA randomized controlled trial.

  Source: Clin Invest Med

• Canadian Network and Centre for Trials Internationally (CANNeCTIN): a national network for Canadian-led trials in cardiovascular diseases and diabetes mellitus.

  Source: Can J Cardiol

• Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis.

  Source: CMAJ

• Pros and cons of composite endpoints in anesthesia trials.

  Source: Anesthesiology

• Testing for heterogeneity among the components of a binary composite outcome in a clinical trial.

  Source: BMC Med Res Methodol

• CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials.

  Source: Obstet Gynecol

• CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials.

  Source: PLoS Med

• CONSORT 2010 Statement: Updated guidelines for reporting parallel group randomised trials.

  Source: J Clin Epidemiol

• CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomised trials.

  Source: J Clin Epidemiol

• Kidney disease after preeclampsia: a systematic review and meta-analysis.

  Source: Am J Kidney Dis

• CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials.

  Source: Ann Intern Med

• CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials.

  Source: BMC Med

• CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials.

  Source: Trials

• CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials.

  Source: BMJ

• CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials.

  Source: BMJ

• Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

  Source: Int J Surg

• Randomized controlled trials of surgical interventions.

  Source: Ann Surg

• The experts debate: perioperative beta-blockade for noncardiac surgery–proven safe or not?

  Source: Cleve Clin J Med

• Anesthesia needs large international clinical trials.

  Source: HSR Proc Intensive Care Cardiovasc Anesth

• Iatrogenic adverse events in the coronary care unit.

  Source: Circ Cardiovasc Qual Outcomes

• Identification of myocardial injury in the emergency setting.

  Source: Clin Biochem

• Carotid endarterectomy benefits patients with CKD and symptomatic high-grade stenosis.

  Source: J Am Soc Nephrol

• Is a pre-operative brain natriuretic peptide or N-terminal pro-B-type natriuretic peptide measurement an independent predictor of adverse cardiovascular outcomes within 30 days of noncardiac surgery? A systematic review and meta-analysis of observational

  Source: J Am Coll Cardiol

• Etiology of troponin elevation in critically ill patients.

  Source: J Crit Care

• Is it safe to use a proton pump inhibitor with clopidogrel?

  Source: Pol Arch Med Wewn

• Reprint–preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

  Source: Phys Ther

• Quality of care in for-profit and not-for-profit nursing homes: systematic review and meta-analysis.

  Source: BMJ

• Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

  Source: J Clin Epidemiol

• The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.

  Source: J Clin Epidemiol

• Large randomized controlled trials in perioperative cardiovascular medicine: a proposal for the design, conduct and efficient management.

  Source: Arq Bras Cardiol

• The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.

  Source: Ann Intern Med

• Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

  Source: Ann Intern Med

• The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration.

  Source: BMJ

• Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

  Source: BMJ

• Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

  Source: PLoS Med

• The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.

  Source: PLoS Med

• Can attenuation of the perioperative stress response prevent intermediate or long-term cardiovascular outcomes among patients undergoing noncardiac surgery?

  Source: Anesthesiology

• Resolving controversies in hip fracture care: the need for large collaborative trials in hip fractures.

  Source: J Orthop Trauma

• Early mobilisation for patients following acute myocardiac infarction: a systematic review and meta-analysis of experimental studies.

  Source: Int J Nurs Stud

• Composite outcomes can distort the nature and magnitude of treatment benefits in clinical trials.

  Source: Ann Intern Med

• Polypharmacotherapy for primary prevention of cardiovascular disease.

  Source: Indian Heart J

• The practicalists’ response.

  Source: J Clin Epidemiol

• The diagnosis of myocardial infarction in critically ill patients: an agreement study.

  Source: J Crit Care

• Nitrous oxide and perioperative cardiac morbidity (ENIGMA-II) Trial: rationale and design.

  Source: Am Heart J

• Optimal method of coronary revascularization in patients receiving dialysis: systematic review.

  Source: Clin J Am Soc Nephrol

• Should physicians initiate beta-blocker therapy in patients undergoing non-cardiac surgery? Insights from the POISE trial.

  Source: Pol Arch Med Wewn

• Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses.

  Source: Am Heart J

• Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients.

  Source: J Am Coll Cardiol

• The quality of reporting of trial abstracts is suboptimal: survey of major general medical journals.

  Source: J Clin Epidemiol

• Statistical issues in the design and analysis of expertise-based randomized clinical trials.

  Source: Stat Med

• Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?

  Source: Int J Epidemiol

• Clinical benefit of steroid use in patients undergoing cardiopulmonary bypass: a meta-analysis of randomized trials.

  Source: Eur Heart J

• How to use an article about a diagnostic test.

  Source: J Urol

• Design considerations for randomised trials in orthopaedic fracture surgery.

  Source: Injury

• Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial.

  Source: Lancet

• A new ‘mechanistic-practical” framework for designing and interpreting randomized trials.

  Source: J Clin Epidemiol

• Orthopaedic surgeons prefer to participate in expertise-based randomized trials.

  Source: Clin Orthop Relat Res

• Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data.

  Source: Lancet

• The use of expertise-based randomized controlled trials to assess spinal manipulation and acupuncture for low back pain: a systematic review.

  Source: Spine (Phila Pa 1976)

• Effect of perioperative insulin infusion on surgical morbidity and mortality: systematic review and meta-analysis of randomized trials.7.

  Source: Mayo Clin Proc

• Open versus endovascular repair of abdominal aortic aneurysm: a survey of Canadian vascular surgeons.

  Source: Can J Surg

• Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings.

  Source: Crit Care

• Chronic kidney disease and postoperative mortality: a systematic review and meta-analysis.

  Source: Kidney Int

• Sensible guidelines for the conduct of large randomized trials.

  Source: Clin Trials

• Symbols were superior to numbers for presenting strength of recommendations to health care consumers: a randomized trial.

  Source: J Clin Epidemiol

• Systematic reviewers neglect bias that results from trials stopped early for benefit.

  Source: J Clin Epidemiol

• Factors associated with citation rates in the orthopedic literature.

  Source: Can J Surg

• Outcomes of patients who participate in randomised controlled trials compared to similar patients receiving similar interventions who do not participate.

  Source: Cochrane Database Syst Rev

• Can troponin I measurement predict short-term serious cardiac outcomes in patients presenting to the emergency department with possible acute coronary syndrome?

  Source: CJEM

• A systematic review of studies comparing health outcomes in Canada and the United States.

  Source: Open Med

• Elevated cardiac troponin measurements in critically ill patients.

  Source: Arch Intern Med

• Strength of evidence for perioperative use of statins to reduce cardiovascular risk: systematic review of controlled studies.

  Source: BMJ

• Incidence and timing of myocardial infarction after total joint arthroplasty.

  Source: J Arthroplasty

• Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery.

  Source: Am Heart J

• Surrogate markers in clinical studies: problems solved or created?

  Source: Am J Kidney Dis

• Compression plating versus intramedullary nailing of humeral shaft fractures–a meta-analysis.

  Source: Acta Orthop

• Misuse of baseline comparison tests and subgroup analyses in surgical trials.

  Source: Clin Orthop Relat Res

• Coronary-artery revascularization before elective major vascular surgery. McFalls EO, ward HB, Moritz TE, Goldman S, Krupski WC, Littooy F, Pierpont G, Santilli S, Rapp J, Hattler B, Shunk K, Jaenicke C, Thottapurathu L, Ellis N, Reda DJ, Henderson WG. N

  Source: Vasc Med

• Elevated cardiac troponin levels in critically ill patients: prevalence, incidence, and outcomes.

  Source: Am J Crit Care

• Reliability of electrocardiogram interpretation in critically ill patients.

  Source: Crit Care Med

• Can contraindications compromise evidence-based, patient-centered clinical practice?

  Source: Can J Clin Pharmacol

• Deep venous thrombosis: clinically silent in the intensive care unit.

  Source: J Crit Care

• Double blind, you are the weakest link–goodbye!

  Source: Equine Vet J

• Elevated troponin and myocardial infarction in the intensive care unit: a prospective study.

  Source: Crit Care

• Randomized trials stopped early for benefit: a systematic review.

  Source: JAMA

• Endovascular and open repair did not differ for mortality rates at 2 years in abdominal aortic aneurysm.

  Source: ACP J Club

• Surveillance and prevention of major perioperative ischemic cardiac events in patients undergoing noncardiac surgery: a review.

  Source: CMAJ

• Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk.

  Source: CMAJ

• Preference-based antithrombotic therapy in atrial fibrillation: implications for clinical decision making.

  Source: Med Decis Making

• Operative management of displaced femoral neck fractures in elderly patients. An international survey.

  Source: J Bone Joint Surg Am

• The quality of randomized trial reporting in leading medical journals since the revised CONSORT statement.

  Source: Contemp Clin Trials

• How strong is the evidence for the use of perioperative beta blockers in non-cardiac surgery? Systematic review and meta-analysis of randomised controlled trials.

  Source: BMJ

• Prophylactic coronary artery revascularization before elective vascular surgery did not improve long-term survival.

  Source: ACP J Club

• Review: population-based screening for abdominal aortic aneurysm reduces cause-specific mortality in older men.

  Source: ACP J Club

• Capability of ischemia-modified albumin to predict serious cardiac outcomes in the short term among patients with potential acute coronary syndrome.

  Source: CMAJ

• Systematic review to determine whether participation in a trial influences outcome.

  Source: BMJ

• An observational study of duplicate presentation rates between two national orthopedic meetings.

  Source: Can J Surg

• Long-term health sequelae following E. coli and campylobacter contamination of municipal water. Population sampling and assessing non-participation biases.

  Source: Can J Public Health

• The standard gamble demonstrated lower reliability than the feeling thermometer.

  Source: J Clin Epidemiol

• Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: a systematic review.

  Source: JAMA

• Need for expertise based randomised controlled trials.

  Source: BMJ

• Do beta-blockers and thiazides reduce fracture risk?

  Source: CMAJ

• Internet versus mailed questionnaires: a controlled comparison (2).

  Source: J Med Internet Res

• An observational study found that authors of randomized controlled trials frequently use concealment of randomization and blinding, despite the failure to report these methods.

  Source: J Clin Epidemiol

• Measurement of agreement on health-related quality of life changes in response to respiratory rehabilitation by patients and physicians–a prospective study.

  Source: Respir Med

• Users’ guide to detecting misleading claims in clinical research reports.

  Source: BMJ

• Perioperative use of atorvastatin reduced cardiovascular events in patients having vascular surgery.

  Source: ACP J Club

• Internet versus mailed questionnaires: a randomized comparison (2).

  Source: J Med Internet Res

• The effect of perioperative beta-blockers on patients undergoing noncardiac surgery – is the answer in?

  Source: Can J Anaesth

• A large trial is vital to prove perioperative beta-blockade effectiveness and safety before widespread use.

  Source: Anesthesiology

• Are the recommendations to use perioperative beta-blocker therapy in patients undergoing noncardiac surgery based on reliable evidence?

  Source: CMAJ

• The impact of time of admission on major complications and mortality in patients undergoing emergency trauma surgery.

  Source: Acta Orthop Scand

• Cerebrospinal fluid drainage to prevent paraplegia during thoracic and thoracoabdominal aortic aneurysm surgery: a systematic review and meta-analysis.

  Source: J Vasc Surg

• Payments for care at private for-profit and private not-for-profit hospitals: a systematic review and meta-analysis.

  Source: CMAJ

• Doubling the impact: publication of systematic review articles in orthopaedic journals.

  Source: J Bone Joint Surg Am

• Best evidence in anesthetic practice. Prevention: alpha2- and beta-adrenergic antagonists reduce perioperative cardiac events.

  Source: Can J Anaesth

• Users’ guide to the surgical literature: how to use a systematic literature review and meta-analysis.

  Source: Can J Surg

• Association between industry funding and statistically significant pro-industry findings in medical and surgical randomized trials.

  Source: CMAJ

• A review of heart failure treatment.

  Source: Mt Sinai J Med

• Patients at the center: in our practice, and in our use of language.

  Source: ACP J Club

• Interpreting authorship order and corresponding authorship.

  Source: Epidemiology

• Challenges to the practice of evidence-based medicine during residents’ surgical training: a qualitative study using grounded theory.

  Source: Acad Med

• Internal fixation compared with arthroplasty for displaced fractures of the femoral neck. A meta-analysis.

  Source: J Bone Joint Surg Am

• A randomized trial of opinion leader endorsement in a survey of orthopaedic surgeons: effect on primary response rates.

  Source: Int J Epidemiol

• The risk of false-positive results in orthopaedic surgical trials.

  Source: Clin Orthop Relat Res

• Methodologic issues in randomized controlled trials of surgical interventions.

  Source: Clin Orthop Relat Res

• The evolution of the randomized controlled trial and its role in evidence-based decision making.

  Source: J Intern Med

• Clinical expertise in the era of evidence-based medicine and patient choice.

  Source: Vox Sang

• Barriers to full-text publication following presentation of abstracts at annual orthopaedic meetings.

  Source: J Bone Joint Surg Am

• Assessment and reporting of perioperative cardiac risk by Canadian general internists: art or science?

  Source: J Gen Intern Med

• Comparison of mortality between private for-profit and private not-for-profit hemodialysis centers: a systematic review and meta-analysis.

  Source: JAMA

• In the dark: the reporting of blinding status in randomized controlled trials.

  Source: J Clin Epidemiol

• User’s guide to the orthopaedic literature: how to use a systematic literature review.

  Source: J Bone Joint Surg Am

• The reporting of methodological factors in randomized controlled trials and the association with a journal policy to promote adherence to the Consolidated Standards of Reporting Trials (CONSORT) checklist.

  Source: Control Clin Trials

• Solving the public health care sustainability puzzle.

  Source: CMAJ

• A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals.

  Source: CMAJ

• Physicians’ and patients’ choices in evidence based practice.

  Source: BMJ

• Double blind, you have been voted off the island!

  Source: Evid Based Ment Health

• Accelerated publication versus usual publication in 2 leading medical journals.

  Source: CMAJ

• An observational study of orthopaedic abstracts and subsequent full-text publications.

  Source: J Bone Joint Surg Am

• Clinical expertise in the era of evidence-based medicine and patient choice.

  Source: ACP J Club

• Double blind, you are the weakest link–good-bye!

  Source: ACP J Club

• Differences between perspectives of physicians and patients on anticoagulation in patients with atrial fibrillation: observational study.

  Source: BMJ

• Transesophageal echocardiography to guide cardioversion in patients with atrial fibrillation.

  Source: N Engl J Med

• Reviewing the reviewers: the quality of reporting in three secondary journals.

  Source: CMAJ

• Physician interpretations and textbook definitions of blinding terminology in randomized controlled trials.

  Source: JAMA

• Physicians’ recommendations for patients who undergo noncardiac surgery.

  Source: Clin Invest Med

• Physician estimates of perioperative cardiac risk in patients undergoing noncardiac surgery.

  Source: Arch Intern Med

• Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery.

  Source: N Engl J Med