Population Health Research Institute
Study List

Remote IMPACT CANNeCTIN Pilot (Ongoing)
Remote IscheMic Preconditioning in CArdiAc Surgery Trial

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The purpose of this CANNeCTIN-funded pilot study is to determine the effect of remote ischemic preconditioning (RIPC) on surrogate endpoints of cardiac and kidney injury and determine what combination of limbs used and number of cycles is most effective. Remote ischemic preconditioning is accomplished by inflating a blood pressure cuff to create ischemia in a limb.  PIs: Drs. Michael Walsh (U. Calgary) and Sabu Thomas (U. Minnesota).

Study Design: This is a six parallel limb RCT comparing 5 regimens of RIPC to a sham procedure comparator group.  Patients, care providers, data collectors, outcome adjudicators and investigators will be blinded to treatment allocation.  Patients will be stratified by surgical type (bypass graft procedure alone vs. other), and preoperative renal function (estimated glomerular filtration rate ≥ 45 ml/min vs. <45 ml/min), and centre.  Research personnel will follow patients in-hospital and contact them at 30 days after surgery recording all the outcome measures.

Intervention: Remote ischemic preconditioning (with blood pressure cuff) compared to sham procedure.  The RIPC regimens vary the limb (i.e. upper, lower, or both) and the number of cycles of RIPC (i.e., 1 versus 3 cycles).

Length of Study: 2 years 

# of Patients: 600 (pilot) 

Patient Populations: Patients undergoing elective cardiac surgery


Available upon study completion.

Main Publications (for a full listing of publications, please visit the 'Media and Publications' section)

Not available at this time.

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