Population Health Research Institute
Study List

SUrgical and Pharmacological novel intERventions to Improve Overall Results of
Saphenous Vein Graft Patency in Coronary Artery Bypass Grafting surgery: An International
Randomized Controlled Clinical Trial

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The ultimate aim of this study is to perform an international multicenter factorial design RCT to see if a novel atraumatic pedicled (no touch) technique of SVG harvesting (surgical arm) and/or the use of oral N-3 polyunsaturated fatty acid (pharmacological arm) improve angiographic patency and clinical outcomes at 1 year compared to conventional SVG harvesting and placebo respectively. This CANNeCTIN-funded pilot study will assess feasibility. PIs: Stephen Fremes and Steve Singh (Sunnybook) and Richard Novick and Michael CHU (UWO)

Study Design:  Factorial Design RCT

Intervention: Novel saphenous vein graft harvesting vs. conventional (single-blinded); N-3 polyunsaturated fatty acid (fish oil) vs. pacebo (double-blinded)

Length of Study:  1.5 years

# of Patients:  50 patients at 8 sites (pilot phase)

Patient Populations: Patients undergoing multiple coronary artery bypass graft surgery.


Available upon study completion.

Main Publications (for a full listing of publications, please visit the 'Media and Publications' section)

Not available at this time.

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Population Health Research Institute • Hamilton, Ontario • information@phri.ca