Population Health Research Institute
Perioperative Ischemia

Perioperative Ischemia
Evaluating vascular events in patients undergoing non-cardiac surgery

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Over 200 million adults globally (500,000 Canadian adults) undergo non-cardiac surgery requiring hospital admission annually. Although non-cardiac surgery provides important benefits, it is associated with major adverse vascular events. 


The Perioperative Ischemia Research Program at the Population Health Research Institute evaluates the epidemiology, pathophysiology, risk prediction, monitoring strategies, prevention, and management of perioperative vascular events.  This multidisciplinary research team has expertise in perioperative vascular medicine and represents the fields of anesthesia, cardiology, emergency medicine, intensive care, internal medicine, laboratory medicine, statistics, stroke, surgery, and thromboembolism.


Main Publications

Devereaux PJ, Yusuf S, Yang H, Choi PTL, Guyatt GH. Are the recommendations to use perioperative blocker therapy in patients undergoing noncardiac surgery based on reliable evidence? CMAJ. 2004; 171; 245-247.

Devereaux PJ, Beattie WS, Choi PTL, Badner NH, Guyatt GH, Villar JC, Cinà CS, Leslie K, Jacka MJ, Montori VM, Bhandari M, Avezum A, Biasi Cavalcante A, Giles JW, Schricker T, Yang H, Jackobsen CJ, Yusuf S. How strong is the evidence for the use of perioperative ßblockers in non-cardiac surgery? A systematic review and meta-analysis of randomized controlled trials. BMJ. 2005; 331: 313-321.

Devereaux, PJ, Goldman L, Cook DJ, Gilbert K, Leslie K, Guyatt GH.  Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk. CMAJ. 2005; 173: 627-634.

Devereaux PJ, Goldman L, Yusuf S, Gilbert K, Leslie K, Guyatt GH.  Surveillance and prevention of major perioperative ischemic cardiac events in patients undergoing noncardiac surgery: A review. CMAJ. 2005; 173: 779-788.

The POISE Investigators. Rationale, design, and organization of the PeriOperative Ischemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery. Am Heart J. 2006; 152: 223-230.

The POISE Study Group. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomized controlled trial.  Lancet 2008; 371: 1839-1847. (fast-tracked article)


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