Population Health Research Institute
Developing Countries

Cardiovascular Diseases &
Related Conditions in Developing Countries

Addressing the burden of disease on a global basis

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During the 20th century high income countries conquered epidemics related to infectious diseases, but experienced marked increases in chronic diseases such as obesity, diabetes and CVD. By contrast, low income countries continue to experience high rates of CVD from infectious diseases (e.g. Chagas disease, rheumatic heart disease and tuberculosis), and with industrialization, urbanization and increased tobacco use, CVD, obesity and diabetes have been rising dramatically. This drastically increases the burden and types of CVD that these countries face, and together with poverty, poor health care services, and limited public health policies comprises a "triple-burden" that leads to an untenable health care situation in these countries.


Overview

The Developing Countries Program at the Population Health Research Institute has been working on exploring the causes of heart disease and strokes globally. They also strive to improve the management of patients with acute coronary syndromes. This specific program has also initiated studies in conditions, which are commonly neglected in research, such as Chagas disease.


Studies


Main Publications

Reddy KS, Yusuf S. Emerging epidemic of cardiovascular disease in developing countries. Circulation 1998; 97(6): 596-601. 

Pais P, Pogue J, Gerstein H, Zachariah E, Savitha D,Jayprakash S, Nayak PR, Yusuf S. Risk factors foracute myocardial infarction in Indians: a case-controlstudy. Lancet 1996; 348: 358-363.

 Yusuf S, Reddy S, Ôunpuu S, Anand S. Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization.Circulation2001; 104(22): 2746-53.

Yusuf S, Reddy S, Ôunpuu S, Anand S. Global burden of cardiovascular diseases: Part II: variations in cardiovascular disease by specific ethnic groups and geographic regions and prevention strategies. Circulation 2001; 104(23): 2855-64.

 Yusuf S, Hawken S, Ôunpuu S, Dans T, Avezum A,Lanas F, McQueen M, Budaj A, Pais P, Varigos J, Lisheng L, on behalf of the INTERHEART investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52countries (the INTERHEART study): case-control study.Lancet 2004; 364(9437): 937-52.

Rosengren A, Hawken S, Ôunpuu S, Sliwa K, ZubaidM, Almahmeed WA, Blackett KN, Sitthi-amorn C,Sato H, Yusuf S for the INTERHEART investigators. Association of psychosocial risk factors with risk of acute myocardial infarction in 11,119 cases and13,648 controls from 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364(9437):953-62.

Steyn K, Sliwa K, Hawken S, Commerford P, Onen C,Damasceno A, Ounpuu S, Yusuf S; INTERHEART Investigators in Africa. Risk factors associated with myocardial infarction in Africa: the INTERHEART Africa study. Circulation 2005; 112(23): 3554-61.

Yusuf  S, Hawken S, Ôunpuu S, Bautista L, FranzosiMG, Commerford P, Lang  CM, Rumboldt  Z, Onen C,Lisheng L, Tanomsup S, Wangai Jr P, Razak F, Sharma AM, Anand S, on behalf of the INTERHEART Study nvestigators. Obesity and the risk of myocardialinfarction in 27,000 subjects from 52 countries. Lancet 2005; 366(9497): 1640-9.

Teo KK, Ounpuu S, Hawken S, Pandey M, Valentin V,Hunt D, Diaz R, Rashed W, Freeman R, Jiang L, ZhangX, Yusuf S, on behalf of the INTERHEART Study Investigators. Tobacco use and risk of myocardial infarction in 52 countries in the INTERHEART study: a case-control study. Lancet 2006; 368 (9536)

Teo KK, Ounpuu S, Hawken S, Pandey M, Valentin V,Hunt D, Diaz R, Rashed W, Freeman R, Jiang L, ZhangX, Yusuf S, on behalf of the INTERHEART Study Investigators. Tobacco use and risk of myocardialinfarction in 52 countries in the INTERHEART study:a case-control study. Lancet 2006; 368 (9536):647-658.

 

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