Population Health Research Institute
Study List

SIRS (Ongoing) 
Steriods In CaRdiac Surgery Trial

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SIRS trial is a large simple study in which patients undergoing cardiac surgery requiring the use of cardiopulmonary bypass (CPB) are randomly allocated to receive a pulse dose of Methylprednisolone or a matching placebo. SIRS will confirm or deny the potential clinical benefits of suppressing this response through the use of systemic steroids.

Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy.

Intervention: Methylprednisolone.

Length of Study: 2 years

# of Patients: 7,000 

Patient Populations: Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome.


Available upon study completion.

Main Publications (for a full listing of publications, please visit the 'Media and Publications' section)

Not available at this time.

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Population Health Research Institute • Hamilton, Ontario • information@phri.ca