Population Health Research Institute
Study List

CURRENT/ OASIS-7 (Completed)
Randomized, Multinational, Double-Blind Study, Comparing a High Loading Dose Regimen of Clopidogrel Versus Standard Dose in Patients with Unstable Angina or Myocardial Infarction Managed with an Early Invasive Strategy

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The purpose of this study is to evaluate whether a higher dosage of clopidogrel with aspirin (two doses) will decrease the risk of ischemic complications (cardiac death, stroke, myocardial infarction) after a percutaneous coronary intervention. the CURRENT-OASIS 7 (Clopidogrel optimal loading dose Usage to Reduce Recurrent EveNTs-Organization to Assess Strategies in Ischemic Syndromes) study will be the first adequately powered randomized trial to determine the efficacy and safety of higher dose compared with lower dose ASA and clopidogrel for treatment of ACS. The results of this large factorial study will have direct relevance to clinical practice worldwide.

Study Design: Treatment, Randomized, Double Blind, Dose Comparison, Factorial Assignment, Efficacy Study

Intervention: High loading dose regimen of clopidogrel. 

Length of Study: 4 years

# of Patients: 25,000

Patient Populations: Acute coronary syndromes with and without ST segment elevation.


Presentations

Available upon request to current@phri.ca.


Main Publications (for a full listing of publications, please visit the 'Media and Publications' section)
 

The CURRENT-OASIS 7 Investigators. Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes. New England Journal of Medicine 2010;363:930-42.

Mehta SR et al. Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. The Lancet Published Online September 2, 2010 DOI:10.1016/S0140-6736(10)61088-4.

Mehta SR, Bassand JP, Chrolavicius S, Diaz R, Fox KA, Granger CB, Jolly S, Rupprecht HJ, Widimsky P, Yusuf S; CURRENT-OASIS 7 Steering Committee. Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy. Am Heart J. 2008;156(6):1080-1088. 

 

 

 

 

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