Population Health Research Institute
Study List

HOPE-3 (Ongoing)
Heart Outcomes Prevention Evaluation

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HOPE-3 is a large, simple trial evaluating the effects of lipid modification and blood pressure lowering and their combination in a wide range of middle aged people, who are at average risk for vascular events.  A total of 12,705 participants were recruited in 21 countries and will be followed for the occurrence of major vascular events over an average of 5 years.  HOPE-3 is expected to identify safe and effective cardiovascular prevention strategies which could substantially reduce the risk of CVD in large proportions of the adult population worldwide.

Study Design: Randomized, Double-Blind, Placebo Control, Factorial Assignment, Safety/Efficacy Study.

Intervention: Rosuvastatin, Candesartan/Hydrochlorothiazide, Factorial vs. placebo.

Length of Study: 7 years

# of Patients: 12,705

Patient Populations: Cardiovascular Disease, Stroke, Asymptomatic individuals at moderate risk for CV events.


Available upon study completion.

Main Publications (for a full listing of publications, please visit the 'Media and Publications' section)

 Not available at this time.


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Population Health Research Institute • Hamilton, Ontario • information@phri.ca