Population Health Research Institute
Study List

CURE/OASIS-4 (Completed)
The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial

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To open a new browser window and visit the CURE website, please click here.

The CURE trial  evaluated the efficacy and safety of  clopidogrel when given with aspirin patients with non- ST-segment elevation acute coronary syndromes. Clopidogrel had beneficial, however, there was an increased risk of major bleeding. The findings of the CURE trial led to widespread use of clopidogrel in non -ST segment elevation ACS patients, modification of practice guidelines and regulatory approvals in many countries around the world. Clopidogrel has become an established therapy in these patients and one of the most commonly used drugs in ACS.

Study Design: Randomized controlled trial. 

Intervention: Clopidogrel with Aspirin vs. Placebo.

Length of Study: 2 years

# of Patients: 12,562

Patient Populations: Patients with non-ST-segment elevation acute coronary syndromes.


CURE Trial Results

Main Publications (A full listing of publications can be found in the 'Media & Publictions' section)

Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK; Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494-502.

Mehta SR, Yusuf S, Peters RJ, Bertrand ME, Lewis BS, Natarajan MK, Malmberg K, Rupprecht H, Zhao F, Chrolavicius S, Copland I, Fox KA; Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study.Lancet. 2001;358(9281):527-33.

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