Population Health Research Institute
Study List

ASSERT (Ongoing)
ASymptomatic AF and Stroke Evaluation in Pacemaker Patients and the AF Reduction Atrial acing Trial

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ASSERT is evaluating the hypothesis that among patients with a standard indication for pacing and no previous history of AF, detection of AHRE predicts an increased risk of stroke and systemic embolism. The second hypothesis to be tested is that overdrive atrial pacing with the AF suppression algorithm will reduce the risk of symptomatic AF in patients with standard indication for pacing and no previous history of AF.

Study Design: Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study.

Intervention: Detection of AHRE predicts an increased risk of stroke and setemic embolism vs. overdrive atrial pacing with the AF suppression. 

Length of Study: 8 years

# of Patients: 2,500

Patient Populations: Atrial Fibrillation, Hypertension.


Presentations

Available upon study completion.


Publications (for a full listing of publications, please visit the 'Media and Publications' section)

Hohnloser SH, Capucci A, Fain E, Gold MR, van Gelder IC, Healey J, Israel CW, Lau CP, Morillo C, Connolly SJ; ASSERT Investigators and Committees. ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT). Am Heart J. 2006;152(3):442-7.

Jeff S. Healey, Stuart J. Connolly, Michael R. Gold, Carsten W. Israel, Isabelle C. Van Gelder, Alessandro Capucci, C.P. Lau, Eric Fain, Sean Yang, Christophe Bailleul, Carlos A. Morillo, Mark Carlson, Ellison Themeles, Elizabeth S. Kaufman, Stefan H. Hohnloser, ASSERT Investigators. Subclinical Atrial Fibrillation and the Risk of Stroke. N Engl J Med 2012; 366: 120 - 129.

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