Population Health Research Institute
Study List

WAVE (Completed)
Warfarin and Antiplatelet Vascular Evaluation

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The WAVE trial was a  phase III international, multi-centres  RCT of warfarin plus antiplatelet therapy versus antiplatelet therapy alone in patients with peripheral arterial disease (one of the largest trials to-date conducted in patients with peripheral arterial disease).

Study Design: Randomized open label parallel group design.

Intervention: Warfarin plus antiplatelet therapy vs. antiplatelet threapy.

Length of Study: 4.5 years.

# of Patients: 2,161.

Patient Populations: Peripheral arterial disease.


Warfarin Antiplatelet Vascular Evaluation - Hotline Presentation

Main Publications (for a full listing of publications, please visit the 'Media and Publications' section)

WAVE Investigators. The effects of oral anticoagulants in patients with peripheral arterial disease: rationale, design, and baseline characteristics of the Warfarin and Antiplatelet Vascular Evaluation (WAVE) trial, including a meta-analysis of trials. Am Heart J 2006;151:1-9.

Warfarin Antiplatelet Vascular Evaluation Trial Investigators, Anand S, Yusuf S, Xie C, Pogue J, Eikelboom J, Budaj A, Sussex B, Liu L, Guzman R, Cina C, Crowell R, Keltai M, Gosselin G. Oral anticoagulant and antiplatelet therapy and peripheral arterial disease. N Engl J Med. 2007;357:217-27.



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