Population Health Research Institute
Study List

RESOLVD Pilot (Completed)
Randomized Evaluation of Strategies for Left Ventricular Dysfunction

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 The RESOLVD Pilot Study was a trial of combination neurohormonal blockade using an angiotensin II antagonist (candesartan), an angiotensin-converting enzyme inhibitor (enalapril) and a beta-blocker (metoprolol) in patients with congestive heart failure (CHF).


Study Design: Randomized, two-stage trial consisting of a three-way comparison (stage I), followed by a 3x2 partial factorial design (stage II).

Intervention: Candesartan vs. beta blocker.

Length of Study: 1.5 years

# of Patients: 768

Patient Populations: Chronic heart failure.


Not available at this time.

Main Publications (for a full listing of publications, please visit the 'Media and Publications' section)

Tsuyuki RT, Yusuf S, Rouleau JL, Maggioni AP, McKelvie RS, Wiecek EM, Wang Y, Pogue J, Teo KK, White M, Avezum Á, Latini R, Held P, Lindgren E, Probstfield J, for the RESOLVD Pilot Study Investigators.  Combination neurohormonal blockade with ACE inhibitors, angiotensin II antagonists, and beta blockers in patients with congestive heart failure: design of the randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study.  Can J of Card 1997;13(12):1166-1174.

McKelvie RS, Yusuf S, Pericak D, Avezum A, Burns RJ, Probstfield J, Tsuyuki RT, White M, Rouleau J, Latini R, Maggioni A, Young J, Pogue J. The RESOLVD Pilot Study Investigators. Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. Circulation. 1999;100(10):1056-64.

McKelvie RS, Rouleau JL, White M, Afzal R, Young JB, Maggioni AP, Held P, Yusuf S. Comparative impact of enalapril, candesartan or metoprolol alone or in combination on ventricular remodelling in patients with congestive heart failure. Eur Heart J. 2003;24 (19):1727-34.

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