Population Health Research Institute
Study List

POISE (Completed)
PeriOperative ISchemic Evaluation

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This trial  evaluated the effects of metoprolol (a beta-blocker drug) on the prevention  heart attacks and deaths around the time of noncardiac surgery. POISE is one of the largest trials in perioperative medicine and has had  a significant impact on guidelines and patterns of practice.

Study Design: Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Efficacy Study.

Intervention: Metoprolol.

Length of Study: 5 years

# of Patients: 8,300 

Patient Populations: Patients with cardiovascular disease or at high-risk undergoing elective and urgent/emergent noncardiac surgical procedures.







Main Publications (for a full listing of publications, please visit the 'Media and Publications' section)

POISE Trial Investigators, Devereaux PJ, Yang H, Guyatt GH, Leslie K, Villar JC, Monteri VM, Choi P, Giles JW, Yusuf S. Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery. Am Heart J. 2006;152(2):223-30.

POISE Study Group; Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, Villar JC, Xavier D, Chrolavicius S, Greenspan L, Pogue J, Pais P, Liu L, Xu S, Málaga G, Avezum A, Chan M, Montori VM, Jacka M, Choi P.. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomized controlled trial. Lancet 2008; 371: 1839-47.

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