Population Health Research Institute
Study List

ORIGIN (Ongoing)
Outcome Reduction With Initial Glargine INtervention

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A Multicenter, International Randomized, 2x2 Factorial Design Study to Evaluate the Effects of Lantus (Insulin Glargine) Versus Standard Care, and of Omega-3 Fatty Acids Versus Placebo, in Reducing Cardiovascular Morbidity and Mortality in High Risk People With Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (IGT) or Early Type 2 Diabetes Mellitus.

Website: www.origintrial.org

Study Design: Treatment, Randomized, Open Label, Active Control, Factorial Assignment, Efficacy Study.

Intervention: Insulin Glargine, Omega-3 Fatty Acids.

Length of Study: 8 years

# of Patients: 12,570

Patient Populations: Cardiovascular Disease and Recent Onset Diabetes or Imparied Fasting Glucoseor Impaired Glucose Tolerance.


Presentations

To be published upon study completion.


Main Publications (A full listing of PHRI publications can be found in the 'Media & Publictions' section)

Origin Trial Investigators, Gerstein H, Yusuf S, Riddle MC, Ryden L, Bosch J. Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: the ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention).Am Heart J. 2008;155:26-32, 32.e1-6. Epub 2007 Nov 26.

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