Population Health Research Institute
Study List

OASIS-Pilot (Completed)
Organization to Assess Strategies for Ischemic Syndromes - Pilot

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The trial compared hirudin vs. heparin administered as a 72 hour infusion post presentation and warfarin vs. standard therapy for 6 months in patients with ST segment elevation acute coronary syndromesHirudin, especially at the medium dose, was superior to heparin in preventing ischemic outcomes there was a reduction in the rate of recurrent ischemic events with moderate-intensity, but not with low intensity warfarin. There was an excess in minor bleeds in the warfarin group.

Study Design: Controlled trial, evaluated 2 doses of hirudin and warfarin a 3x2 design.

Intervention: Hirudin vs. Heparin.

Length of Study: 1.5 years

# of Patients: 909

Patient Populations: Unstable angina or suspected acute myocardial infarction with out  ST elevation.


Presentations

Not available at this time.


Main Publications (for a full listing of publications, please visit the 'Media and Publications' section)

Organization to Assess Strategies for Ischemic Syndromes (OASIS) Investigators. Comparison of the effects of two doses of recombinant hirudin compared with heparin in patients with acute myocardial ischemia without ST elevation: a pilot study. Organization to Assess Strategies for Ischemic Syndromes (OASIS) Investigators. Circulation. 1997 ;96(3):769-77.

Anand SS, Yusuf S, Pogue J, Weitz JI, Flather M. Long-term oral anticoagulant therapy in patients with unstable angina or suspected non-Q-wave myocardial infarction: organization to assess strategies for ischemic syndromes (OASIS) pilot study results. Circulation. 1998;98(11):1064-70

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