Population Health Research Institute
Study List

FAMILY (Ongoing)
Family Atherosclerosis Monitoring In EarLY Life

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To open a new browser window and visit the FAMILY study website, please click here.  

The Family Atherosclerosis Monitoring In Early life (FAMILY) Study is a 10 year study of mothers from the time of pregnancy and their infants, their husbands and oldest child (as available), in which we plan to measure the environmental, metabolic and genetic factors that contribute to the development of excess adiposity and obesity related diseases that can have their beginnings in early childhood.   Assessments include information on nutrition, meal patterns, physical activity, growth, health, risk behaviours, socio-economic status, feeling of well being and blood profiles, including analysis of genetic markers up to 10 years of age. All of this information is analyzed so that we can determine how each of these factors influence development of body fat during childhood and risk of obesity-associated markers of disease at 3, 5 and 10 years of age.  We will also assess the heart health of the parents at the 10 year visit. The results of the FAMILY Cohort study will lead to a better understanding of the role of our genes and their interaction with the fetal/maternal environment in the development of adiposity, pre-diabetes and risk factors for heart disease in early childhood, school age, adolescence and young adulthood. With this knowledge, we can then develop recommendations to help women to have healthier pregnancies, and for better nutrition and lifestyle practices for growing children and young adults. 

Study Design: Observational Study.

Intervention: N/A.

Length of Study: 10 years

# of Patients: 860 families

Patient Populations: Observational Study.


Available upon study completion.

Main Publications (for a full listing of publications, please visit the 'Media and Publications' section)

Morrison KM, Atkinson SA, Teo KK.  Fetal Origins of Coronary Artery Disease in Evidence Based Cardiology, 3rd edition, Ed. S Yusuf, J Cairns, J Camm, E Fallen, B Gersh, BMJ Books, Blackwell Publishing, 2009 In press

Morrison KM, Atkinson SA, Yusuf S, Bourgeois J, McDonald S, McQueen MJ, Persadie R, Hunter B, Pogue J, Teo KK, FAMILY investigators. The Family Atheroscleroisis Monitoring in early life (FAMILY) Study: Rationale, design, and baseline data of a study examining the early determinants of atherosclerosis. Am Heart J 2009, In press.
Morrison KM, et al. Cardiovascular risk factors and non-invasive assessment of subclinical atherosclerosis in youth. Atherosclerosis (2009), doi: 10.1016/j.atherosclerosis.2009.07.034.
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Population Health Research Institute • Hamilton, Ontario • information@phri.ca