Population Health Research Institute
Study List

The Indian Polycap Study (TIPS) (Completed)
A Randomized Double Blind Controlled Trial of the Efficacy and Safety of POLYCAP (Quintapill) Versus Its Components in Subjects With at Least One Additional Cardiovascular Risk Factor

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This study is designed to assess the efficacy and safety of the POLYCAP®, a fixed dose combination containing 5 drugs (an antiplatelet drug; 3 blood pressure lowering agents, a beta blocker, an ACE inhibitor, a diuretic and a statin. It  is the first completed trial of polypill and tets primarily th efeasibility and pharmacological effects of various polypill preparations.

Study Design: Randomized, Double blind, Active control, Parallel assignment, Safety/ Efficacy study.

Intervention: 5 drugs: an antiplatelet drug, a beta blocker, an ACE inhibitor, a diruetic and a statin.

Length of Study: 3 years

# of Patients: 2,050

Patient Populations: Asymotpomatic individuals aged 45-80 years with at least one cardiovascular risk factor.


TIPS/POLYCAP Final Results

Main Publications (A full listing of PHRI publications can be found in the 'Media & Publictions' section)

Xavier D, Pais P, Sigamani A, Pogue J, Afzal R, Yusuf S; Indian Polycap Study (TIPS) Investigators. The need to test the theories behind the Polypill: rationale behind the Indian Polycap Study. Nat Clin Pract Cardiovasc Med. 2009 Feb;6(2):96-7. Epub 2008 Dec 23.

The Indian Polycap Study (TIPS); S Yusuf, P Pais, R Afzal, D Xavier, K Teo, J Eikelboom, A Sigamani, V Mohan, R Gupta, N Thomas. Effects of a poly-capsule (PolycapTM) on risk factors in middle aged individuals without cardiovascular disease. Lancet; in press.

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